Burnout can refer to:
- Burnout (psychology), a psychological term for the experience of long-term exhaustion and diminished interest, especially in one's career
- Burnout (Wildstorm), a Wildstorm Comics Character and member of Gen13
- Burnout (car), when a vehicle's tires are spun so that they smoke
- Burnout (video game), A racing game series created by UK company Criterion Games, with a notable emphasis on dangerous driving and crashes
- Burnout (film), a 1979 film
- Burnout (band), both a rock band from Chicago and a now disbanded punk-rock band from Arkansas.