"Lost Souls" can refer to several things:
* Lost Souls is a 2000 movie directed by Janusz Kamiński and starring Winona Ryder and Elias Koteas
* "Lost Souls" is a 1997 miniseries created by Matthew Schutt.
* ''Lost Souls'' (1992) is the debut novel of horror author Poppy Z. Brite
* Lost Souls is the 2000 debut album by British band Doves.
* Lost Souls is an expansion to the computer game, Earth 2150.
* Lost Souls is a heavy metal band.